David Leitsch Selected Research

Pharmaceutical Preparations

1/2022	Modulation of Iron Import and Metronidazole Resistance in Bacteroides fragilis Harboring a nimA Gene.
1/2019	A review on metronidazole: an old warhorse in antimicrobial chemotherapy.
1/2019	Activity of methylgerambullin from Glycosmis species (Rutaceae) against Entamoeba histolytica and Giardia duodenalis in vitro.
4/2013	Entamoeba histolytica: identification of thioredoxin-targeted proteins and analysis of serine acetyltransferase-1 as a prototype example.
5/2010	The flavin inhibitor diphenyleneiodonium renders Trichomonas vaginalis resistant to metronidazole, inhibits thioredoxin reductase and flavin reductase, and shuts off hydrogenosomal enzymatic pathways.
4/2009	Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance.
8/2007	Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase.

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David Leitsch Research Topics

Disease

11	Infections 01/2022 - 08/2007
4	Giardiasis 01/2020 - 01/2015
3	Amebiasis (Amoebiasis) 11/2021 - 12/2008
2	Diarrhea 01/2020 - 01/2020
2	Parasitic Diseases (Parasitic Disease) 01/2019 - 12/2017
2	Trichomonas Infections 04/2015 - 06/2012
1	Acanthamoeba Keratitis 11/2021
1	Encephalitis (Encephalitis, Rasmussen) 11/2021

Drug/Important Bio-Agent (IBA)

14	Metronidazole (Metric)FDA LinkGeneric 01/2022 - 08/2007
8	4-nitroimidazoleIBA 01/2022 - 08/2007
7	Pharmaceutical PreparationsIBA 01/2022 - 08/2007
3	Auranofin (Ridaura)FDA Link 11/2021 - 05/2013
3	NitroimidazolesIBA 01/2019 - 06/2012
2	Albendazole (Albenza)FDA Link 01/2020 - 01/2015
2	nitazoxanide (NTZ)FDA Link 08/2015 - 01/2015
2	Proteins (Proteins, Gene)FDA Link 04/2013 - 12/2008
2	Tinidazole FDA Link 12/2012 - 06/2012
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	GoldIBA 11/2021
1	Nitro CompoundsIBA 01/2020
1	PhytochemicalsIBA 01/2020
1	LactoferrinIBA 01/2020
1	Propolis (Bee Bread)IBA 01/2020
1	VaccinesIBA 01/2020
1	Reducing AgentsIBA 01/2019
1	Antiparasitic Agents (Antiparasitics)IBA 12/2017
1	fungichromin (pentamycin)IBA 04/2015
1	dithiolIBA 04/2013
1	ThioredoxinsIBA 04/2013
1	Oxidoreductases (Dehydrogenase)IBA 04/2013
1	Messenger RNA (mRNA)IBA 12/2008

Therapy/Procedure

1	Contact Lenses 11/2021
1	Therapeutics 01/2020
1	Drug Therapy (Chemotherapy) 01/2015